Rat C-reactive protein activates the autologous complement system
نویسندگان
چکیده
منابع مشابه
Interactions of C-reactive Protein with the Complement System
Protamine sulfate was found to consume large amounts of C selectively during preincubation with sera of individuals in the "acute phase". Marked depletion of C1, C4, and C2 with minimal, if any, depletion of C3-9, was observed. The consumption was time and temperature dependent, occurring most rapidly and extensively at 37 degrees C, 0.10 M relative salt concentration and pH 7.5-8.0; it require...
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Studies were initiated to localize the C-reactive protein (CRP) binding site on the coUagen-like region (CLR) of Clq. CRP bound preferentially to the A chain of reduced Clq, in contrast to aggregated immunoglobulin G (Agg-IgG), which reacted preferentially with the C chain. A group of Clq A chain peptides, including peptides identical to residues 81-97, 76-92, and 14-26, respectively, were synt...
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Background and purpose: Recently, microbial super antigens have been reported in blood and synovial fluid of rheumatoid arthritis patients. Whether or not, the presence of these super antigens could provoke the induction of serologic diagnostic factors, including CrP in patients? the purpose of this study was to production and purification one of the super antigen C of Staphylococcus aureus and...
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Interactions between C-reactive protein (CRP) and liposomal model membranes containing phosphatidylcholine were investigated. These interactions, in the presence of human serum, resulted in consumption of each of the components of the classical complement pathway (C1-C9) and also resulted in complement-dependent damage and release of trapped glucose from certain types of liposomes. CRP-initiate...
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BACKGROUND We previously demonstrated that vascular injury-induced neointima formation is exaggerated in human C-reactive protein (CRP) transgenic (CRPtg) compared to nontransgenic (NTG) mice. We now test the hypothesis that complement is required for this effect. METHODS AND RESULTS CRPtg and NTG with a normal complement system versus their counterparts lacking expression of complement compo...
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ژورنال
عنوان ژورنال: Immunology
سال: 2003
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.2003.01681.x